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GRs may additionally act independently of binding to GRE by acting as a coactivator of different transcription components (e.g., STAT5) or by modulating chromatin structure by recruiting histone deacetylase and effecting gene silencing.63 As a result of topical steroids also can trigger speedy effects (e.g., pores and skin blanching), it is seemingly that a nongenomic mechanism of action for ICSs happens that is characterised by a fast mobile mechanism of motion and transient vasoconstriction on the microcirculation.
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